2-Chloro-4-(trifluoromethyl)nicotinic acid

2-Chloro-4-(trifluoromethyl)nicotinic acid - Names and Identifiers

Name	2-Chloro-4-(trifluoromethyl)nicotinic acid
Synonyms	2-chloro-4-(trifluoromethyl)nicotinic acid 2-Chloro-4-(trifluoromethyl)nicotinic acid 2-Chloro-4-(trifluoromethyl)pyridine-3-carboxy 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid 3-Pyridinecarboxylic acid, 2-chloro-4-(trifluoromethyl)- 3-pyridinecarboxylic acid, 2-chloro-4-(trifluoromethyl)- 2-Chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2-chloro-4-(trifluoromethyl)pyridine
CAS	590371-81-6
EINECS	637-388-1
InChI	InChI=1/C7H3ClF3NO2/c8-5-4(6(13)14)3(1-2-12-5)7(9,10)11/h1-2H,(H,13,14)

2-Chloro-4-(trifluoromethyl)nicotinic acid - Physico-chemical Properties

Molecular Formula	C7H3ClF3NO2
Molar Mass	225.55
Density	1.604g/cm³
Melting Point	158-159°C
Boling Point	299.501°C at 760 mmHg
Flash Point	134.934°C
Vapor Presure	0.001mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.497

2-Chloro-4-(trifluoromethyl)nicotinic acid - Risk and Safety

Risk Codes	R21/22 - Harmful in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
Hazard Class	IRRITANT

2-Chloro-4-(trifluoromethyl)nicotinic acid - Introduction

2-Chloro-4-(trifluoromethyl)nicotinic acid is an organic compound with the chemical formula C7H3ClF3NO2 and a molecular weight of 227.56g/mol.

Nature:
2-Chloro-4-(trifluoromethyl)nicotinic acid is a solid with a white to pale yellow crystalline appearance. It is soluble in organic solvents such as ethanol and dimethylformamide at normal temperature. Its melting point is around 126°C.

Use:
2-Chloro-4-(trifluoromethyl)nicotinic acid is commonly used as a reaction intermediate in organic synthesis. It can be used to synthesize compounds containing nicotine acyl groups, such as drugs, bioactive molecules, etc. In addition, it also has certain applications in the synthesis of pesticides.

Preparation Method:
2-Chloro-4-(trifluoromethyl)nicotinic acid can be prepared by reacting 2-chloro-4-cyanonicotinic acid with trifluoroformic acid. Specific steps are as follows:
1. 2-Chloro-4-cyaninic acid and trifluoroformic acid were added to the reactor in a molar ratio of 1:1.
2. Heat the reactor to an appropriate temperature and stir the reactants to mix and react.
3. After completion of the reaction, the product was filtered, washed and dried to obtain pure 2-Chloro-4-(trifluoromethyl)nicotinic acid.

Safety Information:
2-Chloro-4-(trifluoromethyl)nicotinic acid will not cause direct harm to human body under normal operating conditions. However, as a chemical, it is still necessary to take necessary safety measures when contacting it. During the operation, care should be taken to prevent it from touching the skin and eyes, and to maintain good ventilation conditions. In addition, the compound should avoid contact with oxidants, strong bases and other substances during storage and transportation, so as not to cause chemical reactions or dangerous situations.

Last Update：2024-04-09 20:52:54